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KMID : 0359920060250050771
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Korean Journal of Nephrology
2006 Volume.25 No. 5 p.771 ~ p.777
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Clinical Characteristics of Uremic Pruritus in Chronic Hemodialysis Patients
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Bae Eun-Hui
Kang Woo-Heon
Park Joung-Woo
Bae Woo-Kyun
Lee Kyun-Sang
Ma Seong-Kwon
Kim Nam-Ho
Choi Ki-Chul
Kim Soo-Wan
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Abstract
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Background : Pruritus is a common, unpleasant symptom in patients on maintenance hemodialysis (HD), however its pathogenesis remains unclear. The aim of this study was to evaluate the prevalence of pruritus in chronic renal failure patients on hemodialysis and to correlate its presence with several clinical and laboratory parameters.
Methods : One hundred seventy patients on maintenance HD were enrolled, Some relevant clinical and laboratory parameters (age, sex, duration of dialysis, type of membrane, underlying renal disease, medications, erythropoietin (EPO) and laboratory findings including hematocrit, creatinine, urea, calcium, phosphorus, parathyroid hormone (PTH), erythrocyte sediment rate (ESR), albumin, β2-microglobulin (β2MG) and lipid profile as well as parameters of adequate dialysis (Kt/Vurea, URR) were evaluated.
Results : Total 170 patients (80 males) were enrolled and pruritus was found in 60 patients (Group , M:F=29:31). One hundred ten patients did not Ⅰ complain pruritus (Group Ⅱ, M : F=51 : 59). Mean age was significantly higher in Group I (59.6±14.8 vs. 54.3±13.6 years, p<0.05). There was no difference in sex, type of membrane, primary renal disease, serum β2MG, ESR, EPO dose, duration of dialysis and serum albumin level. The mean value of Kt/V was higher in Group Ⅱ (1.39± 0.36 vs. 1.51± 0.27, p<0.035).
Conclusion : Pruritus was more common in older patients and low Kt/V, but other clinical characteristics and laboratory findings were not correlated with uremic pruritus. (Korean J Nephrol 2006; 25(5):771-777)
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KEYWORD
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Uremic pruritus, Hemodialysis, Kt/V
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